Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates

Hdl Handle:
http://hdl.handle.net/11285/622456
Title:
Oxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates
Authors:
Hernández-Trejo, María; Montoya-Estrada, Araceli; Torres-Ramos, Yessica; Espejel-Núñez, Aurora; Guzmán-Grenfell, Alberto; Morales-Hernández, Rosa; Tolentino-Dolores, Maricruz; Laresgoiti-Servitje, Estibalitz; Hernández-Trejo, María; Montoya-Estrada, Araceli; Torres-Ramos, Yessica; Espejel-Núñez, Aurora; Guzmán-Grenfell, Alberto; Morales-Hernández, Rosa; Tolentino-Dolores, Maricruz; Laresgoiti-Servitje, Estibalitz ( 0000-0002-3271-9955 )
Issue Date:
07/01/2017
Abstract:
Abstract Background Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included in this study to assess the presence of oxidative stress biomarkers and their relationship with serum cytokine concentrations. Oxidative stress biomarkers and antioxidant enzymes were compared between the mother/offspring pairs. The presence of 27 cytokines was measured in maternal and cord blood samples. Analyses were initially performed between all mothers and newborns and later between normal weight and mothers with overweight and obesity, and diabetic/non-diabetic women. Results Significant differences were found in biomarker concentrations between mothers and newborns. Additionally, superoxide-dismutase activity was higher in pre-pregnancy overweight mothers compared to those with normal weight. Activity for this enzyme was higher in neonates born from mothers with normal pregestational weight compared with their mothers. Nitrites in overweight/obese mothers were statistically lower than in their offspring. Maternal free fatty acids, nitrites, carbonylated proteins, malondialdehyde and superoxide dismutase predicted maternal serum concentrations of IL-4, IL-13, IP-10 and MIP-1β. Arginase activity in maternal plasma was related to decreased concentrations of IL-4 and IL-1β in cord arterial blood. Increased maternal malondialdehyde plasma was associated with higher levels of IL-6 and IL-7 in the offspring. Conclusions Oxidative stress biomarkers differ between mothers and offspring and can predict maternal and newborn cytokine concentrations, indicating a potential role for oxidative stress in foetal metabolic and immunologic programming. Moreover, maternal obesity and diabetes may affect maternal microenvironments, and oxidative stress related to these can have an impact on the placenta and foetal growth.
Type:
Journal Article
Appears in Collections:
Artículos de Revistas

Full metadata record

DC FieldValue Language
dc.contributor.authorHernández-Trejo, María-
dc.contributor.authorMontoya-Estrada, Araceli-
dc.contributor.authorTorres-Ramos, Yessica-
dc.contributor.authorEspejel-Núñez, Aurora-
dc.contributor.authorGuzmán-Grenfell, Alberto-
dc.contributor.authorMorales-Hernández, Rosa-
dc.contributor.authorTolentino-Dolores, Maricruz-
dc.contributor.authorLaresgoiti-Servitje, Estibalitz-
dc.contributor.authorHernández-Trejo, Maríaes
dc.contributor.authorMontoya-Estrada, Aracelies
dc.contributor.authorTorres-Ramos, Yessicaes
dc.contributor.authorEspejel-Núñez, Auroraes
dc.contributor.authorGuzmán-Grenfell, Albertoes
dc.contributor.authorMorales-Hernández, Rosaes
dc.contributor.authorTolentino-Dolores, Maricruzes
dc.contributor.authorLaresgoiti-Servitje, Estibalitzes
dc.date.accessioned2017-05-05T21:20:34Z-
dc.date.available2017-05-05T21:20:34Z-
dc.date.issued07/01/2017-
dc.identifier.citationBMC Immunology. 2017 Jan 07;18(1):3-
dc.identifier.urihttp://dx.doi.org/10.1186/s12865-016-0184-6-
dc.identifier.urihttp://hdl.handle.net/11285/622456-
dc.description.abstractAbstract Background Oxidative damage present in obese/overweight mothers may lead to further oxidative stress conditions or inflammation in maternal and cord blood samples. Thirty-four pregnant women/newborn pairs were included in this study to assess the presence of oxidative stress biomarkers and their relationship with serum cytokine concentrations. Oxidative stress biomarkers and antioxidant enzymes were compared between the mother/offspring pairs. The presence of 27 cytokines was measured in maternal and cord blood samples. Analyses were initially performed between all mothers and newborns and later between normal weight and mothers with overweight and obesity, and diabetic/non-diabetic women. Results Significant differences were found in biomarker concentrations between mothers and newborns. Additionally, superoxide-dismutase activity was higher in pre-pregnancy overweight mothers compared to those with normal weight. Activity for this enzyme was higher in neonates born from mothers with normal pregestational weight compared with their mothers. Nitrites in overweight/obese mothers were statistically lower than in their offspring. Maternal free fatty acids, nitrites, carbonylated proteins, malondialdehyde and superoxide dismutase predicted maternal serum concentrations of IL-4, IL-13, IP-10 and MIP-1β. Arginase activity in maternal plasma was related to decreased concentrations of IL-4 and IL-1β in cord arterial blood. Increased maternal malondialdehyde plasma was associated with higher levels of IL-6 and IL-7 in the offspring. Conclusions Oxidative stress biomarkers differ between mothers and offspring and can predict maternal and newborn cytokine concentrations, indicating a potential role for oxidative stress in foetal metabolic and immunologic programming. Moreover, maternal obesity and diabetes may affect maternal microenvironments, and oxidative stress related to these can have an impact on the placenta and foetal growth.-
dc.rightsOpen Access-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleOxidative stress biomarkers and their relationship with cytokine concentrations in overweight/obese pregnant women and their neonates-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2017-05-05T13:57:03Z-
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