Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis

Hdl Handle:
http://hdl.handle.net/11285/613125
Title:
Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
Authors:
Duval, Florent; Moreno Cuevas, Jorge E. ( 0000-0001-5730-1769 ) ; González Garza y Barrón, María T. ( 0000-0002-2442-8453 ) ; Rodríguez Montalvo, Carlos; Cruz Vega, Delia E. ( 0000-0001-8413-1742 )
Issue Date:
24/12/2014
Publisher:
Springer Open
Discipline:
Ciencias de la Salud / Health Sciences
Abstract:
Abstract During chronic liver injury, hepatic stellate cells (HSC) are activated and proliferate, which causes excessive extracellular matrix (ECM) deposition, leading to scar formation and fibrosis. Medicinal plants are gaining popularity as antifibrotic agents, and are often safe, cost-effective, and versatile. This review aims to describe the protective role and mechanisms of medicinal plants in the inhibition of HSC activation and ECM deposition during the pathogenesis of liver fibrosis. A systematic literature review on the anti-fibrotic mechanisms of hepatoprotective plants was performed in PubMed, which yielded articles about twelve relevant plants. Many of these plants act via disruption of the transforming growth factor beta 1 signaling pathway, possibly through reduction in oxidative stress. This reduction could explain the inhibition of HSC activation and reduction in ECM deposition. Medicinal plants could be a source of anti-liver fibrosis compounds.
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/25606051
Type:
Artículo / Article
Appears in Collections:
Artículos de Revistas

Full metadata record

DC FieldValue Language
dc.contributor.authorDuval, Florenten
dc.contributor.authorMoreno Cuevas, Jorge E.en
dc.contributor.authorGonzález Garza y Barrón, María T.en
dc.contributor.authorRodríguez Montalvo, Carlosen
dc.contributor.authorCruz Vega, Delia E.en
dc.date.accessioned2016-06-14T19:13:54Z-
dc.date.available2016-06-14T19:13:54Z-
dc.date.issued24/12/2014-
dc.identifier.pmid25606051-
dc.identifier.otherChinese Medicine. 2014 Dec 24;9(1):27-
dc.identifier.urihttp://dx.doi.org/10.1186/s13020-014-0027-4-
dc.identifier.urihttp://hdl.handle.net/11285/613125-
dc.description.abstractAbstract During chronic liver injury, hepatic stellate cells (HSC) are activated and proliferate, which causes excessive extracellular matrix (ECM) deposition, leading to scar formation and fibrosis. Medicinal plants are gaining popularity as antifibrotic agents, and are often safe, cost-effective, and versatile. This review aims to describe the protective role and mechanisms of medicinal plants in the inhibition of HSC activation and ECM deposition during the pathogenesis of liver fibrosis. A systematic literature review on the anti-fibrotic mechanisms of hepatoprotective plants was performed in PubMed, which yielded articles about twelve relevant plants. Many of these plants act via disruption of the transforming growth factor beta 1 signaling pathway, possibly through reduction in oxidative stress. This reduction could explain the inhibition of HSC activation and reduction in ECM deposition. Medicinal plants could be a source of anti-liver fibrosis compounds.en
dc.language.isoenen
dc.publisherSpringer Openen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25606051en
dc.rightsOpen Access-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleProtective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosisen
dc.typeArtículo / Articleen
dc.identifier.pmcidPMC4299307-
dc.rights.holderDuval et al.; licensee BioMed Central.-
dc.date.updated2016-06-01T12:19:31Z-
dc.subject.disciplineCiencias de la Salud / Health Sciences-

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