Reference values for amino acids and acylcarnitines in peripheral blood in Quarter horses and American Miniature horses

Hdl Handle:
http://hdl.handle.net/11285/612121
Title:
Reference values for amino acids and acylcarnitines in peripheral blood in Quarter horses and American Miniature horses
Authors:
Rodríguez-Sánchez, Irám P.; Treviño Alvarado, Víctor M. ( 0000-0002-7472-9844 ) ; del Rosario Torres-Sepúlveda, María; López Saldaña, Liliana A.; Ponce García, Gustavo; López Uriarte, Graciela A.; del Consuelo Ruiz-Herrera, María; Zamora Ávila, Diana E.; Villarreal Pérez, Jesús Z.; Dávalos Aranda, Guillermo; Martínez de Villarreal, Laura E.
Issue Date:
29/09/2015
Publisher:
Springer Open
Discipline:
Ciencias de la Salud / Health Sciences
Abstract:
Abstract Background Free amino acids and acylcarnitines circulating in the blood can be used for diagnosis for metabolic illness and imbalances. To date, the normal reference ranges of amino acids and acylcarnitines in horse peripheral blood have not been established. In this study, the concentrations of 12 amino acids and 26 acylcarnitines were determined by tandem mass spectrometry in complete blood from 100 healthy horses (50 Quarter horses (QH) [23 males and 27 females] and 50 American Miniature horses (AMH) [15 males and 35 females]) with no signs of metabolic disease. The means and standard deviations were determined and data statistically analyzed. Findings Concentrations of short, medium, and long chain acylcarnitines were significantly higher in male AMH than in male QH. The concentrations of the amino acids alanine, arginine, glycine, proline (glycogenic), and leucine (ketogenic) were higher in the QH than in the AMH. Female AMH had higher concentrations of propionylcarnitine, leucine, proline, arginine, and ornithine than female QH. Conclusions Normal reference ranges of amino acids and acylcarnitines were established for AMH and QH. Significant differences were found in concentration of these compounds between breeds and gender.
Keywords:
Amino acid; Acylcarnitine; Metabolic profile; Miniature horse; Quarter horse; Tandem mass spectrometry
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587867/
Type:
Artículo / Article
Appears in Collections:
Artículos de Revistas

Full metadata record

DC FieldValue Language
dc.contributor.authorRodríguez-Sánchez, Irám P.en
dc.contributor.authorTreviño Alvarado, Víctor M.en
dc.contributor.authordel Rosario Torres-Sepúlveda, Maríaen
dc.contributor.authorLópez Saldaña, Liliana A.en
dc.contributor.authorPonce García, Gustavoen
dc.contributor.authorLópez Uriarte, Graciela A.en
dc.contributor.authordel Consuelo Ruiz-Herrera, Maríaen
dc.contributor.authorZamora Ávila, Diana E.en
dc.contributor.authorVillarreal Pérez, Jesús Z.en
dc.contributor.authorDávalos Aranda, Guillermoen
dc.contributor.authorMartínez de Villarreal, Laura E.en
dc.date.accessioned2016-06-07T20:31:38Z-
dc.date.available2016-06-07T20:31:38Z-
dc.date.issued29/09/2015-
dc.identifier.otherActa Veterinaria Scandinavica. 2015 Sep 29;57(1):62-
dc.identifier.urihttp://dx.doi.org/10.1186/s13028-015-0144-9-
dc.identifier.urihttp://hdl.handle.net/11285/612121-
dc.description.abstractAbstract Background Free amino acids and acylcarnitines circulating in the blood can be used for diagnosis for metabolic illness and imbalances. To date, the normal reference ranges of amino acids and acylcarnitines in horse peripheral blood have not been established. In this study, the concentrations of 12 amino acids and 26 acylcarnitines were determined by tandem mass spectrometry in complete blood from 100 healthy horses (50 Quarter horses (QH) [23 males and 27 females] and 50 American Miniature horses (AMH) [15 males and 35 females]) with no signs of metabolic disease. The means and standard deviations were determined and data statistically analyzed. Findings Concentrations of short, medium, and long chain acylcarnitines were significantly higher in male AMH than in male QH. The concentrations of the amino acids alanine, arginine, glycine, proline (glycogenic), and leucine (ketogenic) were higher in the QH than in the AMH. Female AMH had higher concentrations of propionylcarnitine, leucine, proline, arginine, and ornithine than female QH. Conclusions Normal reference ranges of amino acids and acylcarnitines were established for AMH and QH. Significant differences were found in concentration of these compounds between breeds and gender.en
dc.language.isoenen
dc.publisherSpringer Openen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587867/en
dc.rightsOpen Access-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleReference values for amino acids and acylcarnitines in peripheral blood in Quarter horses and American Miniature horsesen
dc.typeArtículo / Articleen
dc.identifier.pmcidPMC4587867-
dc.rights.holderRodríguez-Sánchez et al.-
dc.date.updated2016-06-01T12:19:25Z-
dc.subject.keywordAmino aciden
dc.subject.keywordAcylcarnitineen
dc.subject.keywordMetabolic profileen
dc.subject.keywordMiniature horseen
dc.subject.keywordQuarter horseen
dc.subject.keywordTandem mass spectrometryen
dc.subject.disciplineCiencias de la Salud / Health Sciences-
All Items in REPOSITORIO DEL TECNOLOGICO DE MONTERREY are protected by copyright, with all rights reserved, unless otherwise indicated.