Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee

Hdl Handle:
http://hdl.handle.net/11285/612120
Title:
Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
Authors:
González Alvarez, Rafael; Garza Rodríguez, María; Delgado Enciso, Iván; Treviño Alvarado, Víctor M. ( 0000-0002-7472-9844 ) ; Canales Del Castillo, Ricardo; Martínez De Villarreal, Laura E.; Lugo Trampe, Ángel; Tejero, María E.; Schlabritz Loutsevitch, Natalia E.; Rocha Pizaña, María; Cole, Shelley A.; Reséndez Pérez, Diana; Moises Alvarez, Mario; Comuzzie, Anthony G.; Barrera Saldaña, Hugo A.; Garza Guajardo, Raquel; Barboza Quintana, Oralia; Rodríguez Sánchez, Irám P.
Issue Date:
12/06/2015
Publisher:
Springer Open
Discipline:
Ciencias de la Salud / Health Sciences
Abstract:
Abstract Background Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. To do that, we performed A RT-PCR from different tissues obtained during necropsies. Also we tested the hypotheses of positive evolution, purifying selection, and neutrality. And finally a phylogenetic analysis was made between primates RARRES2 protein. Results RARRES2 transcripts were present in liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus and pituitary tissues. Expression in kidney and leukocytes were not detectable in either species. It was determined that the studied genes are orthologous. Conclusions RARRES2 evolution fits the hypothesis of purifying selection. Expression profiles of the RARRES2 gene are similar in baboons and chimpanzees and are also phylogenetically related.
Keywords:
Retinoic acid receptor; Responder protein; Primate; Chemerin; TIG2; Tazarotene-induced gene 2 protein; Gene expression
Sponsors:
CONACYT Proyecto N° 167697; CONACYT Proyecto N° 157965
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/26063455
Type:
Artículo / Article
Appears in Collections:
Artículos de Revistas

Full metadata record

DC FieldValue Language
dc.contributor.authorGonzález Alvarez, Rafaelen
dc.contributor.authorGarza Rodríguez, Maríaen
dc.contributor.authorDelgado Enciso, Ivánen
dc.contributor.authorTreviño Alvarado, Víctor M.en
dc.contributor.authorCanales Del Castillo, Ricardoen
dc.contributor.authorMartínez De Villarreal, Laura E.en
dc.contributor.authorLugo Trampe, Ángelen
dc.contributor.authorTejero, María E.en
dc.contributor.authorSchlabritz Loutsevitch, Natalia E.en
dc.contributor.authorRocha Pizaña, Maríaen
dc.contributor.authorCole, Shelley A.en
dc.contributor.authorReséndez Pérez, Dianaen
dc.contributor.authorMoises Alvarez, Marioen
dc.contributor.authorComuzzie, Anthony G.en
dc.contributor.authorBarrera Saldaña, Hugo A.en
dc.contributor.authorGarza Guajardo, Raquelen
dc.contributor.authorBarboza Quintana, Oraliaen
dc.contributor.authorRodríguez Sánchez, Irám P.en
dc.date.accessioned2016-06-07T20:01:30Z-
dc.date.available2016-06-07T20:01:30Z-
dc.date.issued12/06/2015-
dc.identifier.pmid26063455-
dc.identifier.otherBiological Research. 2015 Jun 12;48(1):31-
dc.identifier.urihttp://dx.doi.org/10.1186/s40659-015-0020-0-
dc.identifier.urihttp://hdl.handle.net/11285/612120-
dc.description.abstractAbstract Background Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. To do that, we performed A RT-PCR from different tissues obtained during necropsies. Also we tested the hypotheses of positive evolution, purifying selection, and neutrality. And finally a phylogenetic analysis was made between primates RARRES2 protein. Results RARRES2 transcripts were present in liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus and pituitary tissues. Expression in kidney and leukocytes were not detectable in either species. It was determined that the studied genes are orthologous. Conclusions RARRES2 evolution fits the hypothesis of purifying selection. Expression profiles of the RARRES2 gene are similar in baboons and chimpanzees and are also phylogenetically related.en
dc.description.sponsorshipCONACYT Proyecto N° 167697en
dc.description.sponsorshipCONACYT Proyecto N° 157965en
dc.language.isoenen
dc.publisherSpringer Openen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/26063455en
dc.rightsOpen Access-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleMolecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzeeen
dc.typeArtículo / Articleen
dc.identifier.pmcidPMC4504400-
dc.rights.holderGonzález-Alvarez et al.-
dc.date.updated2016-06-01T12:19:34Z-
dc.subject.keywordRetinoic acid receptoren
dc.subject.keywordResponder proteinen
dc.subject.keywordPrimateen
dc.subject.keywordChemerinen
dc.subject.keywordTIG2en
dc.subject.keywordTazarotene-induced gene 2 proteinen
dc.subject.keywordGene expressionen
dc.subject.disciplineCiencias de la Salud / Health Sciences-

Related articles on PubMed

All Items in REPOSITORIO DEL TECNOLOGICO DE MONTERREY are protected by copyright, with all rights reserved, unless otherwise indicated.