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dc.contributor.advisorGutiérrez Uribe, Janet Alejandraen_US
dc.contributor.advisorAntunes Ricardo, Marilenaen_US
dc.contributor.authorSerna Guerrero, Delia Ayleden_US
dc.date.accessioned2018-06-01T16:43:25Z
dc.date.available2018-06-01T16:43:25Z
dc.date.issued2017-12-01
dc.identifier.urihttp://hdl.handle.net/11285/630026
dc.description.abstractSupplements have increase the popularity of herbal medicine as complementary and/or alternative therapies in the treatment of many disorders, because of this there is a potential possibility for pharmacokinetic and pharmacodynamics interaction between xenobiotics. The health promoting effects of natural foods and dietary supplements containing herbal constituents is believed to be caused by the antioxidant activity of flavonoids. Black bean flavonoids have been shown to have biological effects as antimicrobials, anti-inflammatory, anticholesterolemic, and have anticancerous properties. These interactions can attenuate or enhance drug effects and toxicity by interfering with permeability, phase I metabolism and the antioxidant activity of flavonoids. Keywords: pharmacokinetics, pharmacodynamics, drug interactions, CyP450, hepatocytes, HepG2, Caco2, permeability, cellular antioxidant activity, flavonoids, black bean, quercetin, kaempferol, CPC
dc.language.isoengen_US
dc.rightsOpen Accessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleChanges in the activity of CYP450 3A4 induced by kaempferol 3-O-glucoside, major flavonol found in black bean (Phaseolus vulgaris) seed coat extract.en_US
dc.typeTesis de Maestríaes
thesis.degree.grantorInstituto Tecnológico y de Estudios Superiores de Monterreyes
thesis.degree.levelMaster of Science in Biotechnologyen_US
dc.contributor.committeememberHernández Hernández, José Ascenciónen_US
dc.contributor.committeememberAntunes Ricardo, Marilenaen_US
thesis.degree.disciplineSchool of Engineering and Sciencesen_US
thesis.degree.nameMaestria en Biotecnologíaen_US
dc.subject.keyworddrug interactionsen_US
dc.subject.keywordCyP450en_US
dc.subject.keywordpermeabilityen_US
dc.subject.keywordcellular antioxidant activityen_US
dc.subject.keywordbiotechnologyen_US
thesis.degree.programCampus Monterreyen_US
dc.subject.disciplineCiencias / Sciencesen_US
refterms.dateFOA2018-06-01T16:43:26Z
html.description.abstract<html> <head> <title></title> </head> <body> <p>Supplements have increase the popularity of herbal medicine as complementary and/or alternative therapies in the treatment of many disorders, because of this there is a potential possibility for pharmacokinetic and pharmacodynamics interaction between xenobiotics. The health promoting effects of natural foods and dietary supplements containing herbal constituents is believed to be caused by the antioxidant activity of flavonoids. Black bean flavonoids have been shown to have biological effects as antimicrobials, anti-inflammatory, anticholesterolemic, and have anticancerous properties. These interactions can attenuate or enhance drug effects and toxicity by interfering with permeability, phase I metabolism and the antioxidant activity of flavonoids. Keywords: pharmacokinetics, pharmacodynamics, drug interactions, CyP450, hepatocytes, HepG2, Caco2, permeability, cellular antioxidant activity, flavonoids, black bean, quercetin, kaempferol, CPC</p> </body> </html>en_US


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