Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
AuthorsGonzález Alvarez, Rafael
Garza Rodríguez, María
Delgado Enciso, Iván
Treviño Alvarado, Víctor M.
Canales Del Castillo, Ricardo
Martínez De Villarreal, Laura E.
Lugo Trampe, Ángel
Tejero, María E.
Schlabritz Loutsevitch, Natalia E.
Rocha Pizaña, María
Cole, Shelley A.
Reséndez Pérez, Diana
Moises Alvarez, Mario
Comuzzie, Anthony G.
Barrera Saldaña, Hugo A.
Garza Guajardo, Raquel
Barboza Quintana, Oralia
Rodríguez Sánchez, Irám P.
DisciplineCiencias de la Salud / Health Sciences
KeywordsRetinoic acid receptor
Tazarotene-induced gene 2 protein
MetadataShow full item record
AbstractAbstract Background Chemerin, encoded by the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described function in vascular tone regulation, liver, steatosis, etc. This molecule is believed to represent a critical endocrine signal linking obesity to diabetes. There are no data available regarding evolution of RARRES2 in non-human primates and great apes. Expression profile and orthology in RARRES2 genes are unknown aspects in the biology of this multigene family in primates. Thus; we attempt to describe expression profile and phylogenetic relationship as complementary knowledge in the function of this gene in primates. To do that, we performed A RT-PCR from different tissues obtained during necropsies. Also we tested the hypotheses of positive evolution, purifying selection, and neutrality. And finally a phylogenetic analysis was made between primates RARRES2 protein. Results RARRES2 transcripts were present in liver, lung, adipose tissue, ovary, pancreas, heart, hypothalamus and pituitary tissues. Expression in kidney and leukocytes were not detectable in either species. It was determined that the studied genes are orthologous. Conclusions RARRES2 evolution fits the hypothesis of purifying selection. Expression profiles of the RARRES2 gene are similar in baboons and chimpanzees and are also phylogenetically related.
SponsorsCONACYT Proyecto N° 167697
CONACYT Proyecto N° 157965
TypeArtículo / Article
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/4.0/
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